| DATE | TEAMS | TIME | LOCATION |
| 8/22/2025 | Scranton Prep at Valley View | 7:00 PM | John Henzes Memorial Stadium |
| 8/29/2025 | Loyola Blakefield at Scranton Prep | 6:00 PM | Dunmore High School |
| 9/5/2025 | Old Forge at Mid Valley | 7:00 PM | Mid Valley High School |
| 9/6/2025 | Scranton Prep at Canisius (NY) | 1:00 PM | Koessler Field |
| 9/12/2025 | Delaware Valley at Scranton Prep | 7:00 PM | Dunmore High School |
| 9/19/2025 | Scranton at Scranton Prep | 7:00 PM | Dunmore High School |
| 9/20/2025 | North Pocono at Abington Heights | 1:00 PM | Abington Heights Football Stadium |
| 9/26/2025 | Scranton Prep at Lake Wallenpaupack | 7:00 PM | Wallenpaupack High School |
| 9/27/2025 | Riverside at Susquehanna | 1:00 PM | William Eminger Field |
| 10/3/2025 | Scranton Prep at Abington Heights | 7:00 PM | Abington Heights Football Stadium |
| 10/10/2025 | Scranton Prep at Mid Valley | 7:00 PM | Mid Valley High School |
| 10/11/2025 | Lackawanna Trail at Susquehanna | 1:00 PM | William Eminger Field |
| 10/17/2025 | Jersey Shore at Scranton Prep | 7:00 PM | Dunmore High School |
| 10/24/2025 | North Pocono at Scranton Prep | 7:00 PM | Dunmore High School |
